3-formyl-1H-Indole-4-carboxylic acid methyl ester

3-formyl-1H-Indole-4-carboxylic acid methyl ester - Names and Identifiers

Name	Methyl 3-formyl-1H-indole-4-carboxylate
Synonyms	Methyl-3-Formylindole-4-carboxylate Methyl 3-carboxaldehyde-4-carboxylate Methyl 3-formyl-1H-indole-4-carboxylate 3-Formylindole-4-carboxylic acid methyl ester 3-formyl-1H-Indole-4-carboxylic acid methyl ester 3-Formyl-1H-indole-4-carboxylic acid methyl ester 1H-indole-4-carboxylic acid, 3-formyl-, methyl ester 4-(Methoxycarbonyl)-1H-indole-3-carboxaldehyde, 3-Formyl-4-(methoxycarbonyl)-1H-indole
CAS	53462-88-7
InChI	InChI=1/C11H9NO3/c1-15-11(14)8-3-2-4-9-10(8)7(6-13)5-12-9/h2-6,12H,1H3

3-formyl-1H-Indole-4-carboxylic acid methyl ester - Physico-chemical Properties

Molecular Formula	C11H9NO3
Molar Mass	203.19
Density	1.341±0.06 g/cm3(Predicted)
Melting Point	134-135 °C(Solv: benzene (71-43-2))
Boling Point	404.4±25.0 °C(Predicted)
Flash Point	198.383°C
Vapor Presure	0mmHg at 25°C
pKa	14.30±0.30(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.677

3-formyl-1H-Indole-4-carboxylic acid methyl ester - Risk and Safety

Hazard Class

IRRITANT

3-formyl-1H-Indole-4-carboxylic acid methyl ester - Introduction

Methyl is an organic compound with the chemical formula C12H9NO3.

Nature:
-Appearance: Colorless or pale yellow crystalline solid.
-Melting point: about 132-135°C.
-Stability: Stable at room temperature.

Use:
- Methyl is an important organic synthesis intermediate, which can be used to synthesize indole compounds.
-It has potential anti-tumor and antibacterial activities in the pharmaceutical field, so it may be used in drug research and development.

Preparation Method:
Methyl can be synthesized by the following steps:
1.3-indole -4-carboxylic acid methyl ester reacts with acetic anhydride under alkaline conditions to generate 3-methyl formate -1H-indole -4-carboxylic acid methyl ester.
2. The above intermediate is oxidized with PCC (phosphorus pentachloride) in an appropriate solvent to obtain Methyl.

Safety Information:
- Methyl may cause irritation to eyes, skin and respiratory system. Wear protective glasses and gloves when in contact.
-Avoid inhaling its dust or vapor, and operate in a well-ventilated place.
-should be sealed when stored, away from fire and oxidant.
-When using or handling the substance, please follow the relevant safe handling and disposal regulations.

Last Update：2024-04-09 02:00:46